GeneDistillery

GeneDistiller 2014

 help / manual
disclaimer
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species build display online help (check this to see pop-up descriptions for each element)
order / prioritise genes

display options show hide

target genes show hide
linkage interval
chromosome from to
bp/Mbp (NCBI Build 37)
Values below 400 will be converted to Mbp. If (from) or (to) is not specified, the telomer will be used.
gene symbol
dbSNP ID / Affymetrix ID
microsatellite
type
 
 
single genes / gene lists
HGNC gene symbols / NCBI Entrez gene IDs

Gene symbols and IDs must be comma-separated. * and % can be used as wildcards for gene symbols.

whole genome analysis
mitochondriome analysis
   whole genome analysis    mitochondrial genes à la MitoCarta

known disease genes
OMIM IDs or keywords

comparison with known genes show hide
  compare expression search for interactions
compare with these genes (Entrez gene ID / HGNC gene symbol)
(NCBI Gene ID or gene symbol; comma separated)
compare with these OMIM entries (ID or keyword)
(OMIM ID; comma separated)
limit to genes with a similar expression cut-off value

phenotypes show hide
highlight these...show only genes...
highlight these keywords (OMIM/GeneRIFs) with at least one of these words in their OMIM reports
highlight these HPO IDs (and their subclasses) to which at least one of these HPO IDs applies
highlight these MGD phenotypes to which at least one of these phenotypes was assigned
highlight these GO IDs (and their subclasses) to which at least one of these GO IDs applies
highlight these Kegg pathways (specified by number) involved in at least one of these Kegg pathways

expression show hide

cellular localisation show hide
Select cellular compartments (or locations within them) to be highlighted.
Restrict output to genes/proteins within one of the selected compartments.
         
cell
  cell surface
  plasma membrane
  intracellular part
  ubiquitin ligase complex
  proteasome complex
  cytoskeleton
  nucleus
  nuclear membrane
  nuclear chromosome
  nucleoplasm
  cytoplasmic part
  cytosol
  signal recognition particle
  inclusion body
  glycosome
  peroxisome
  endosome
  lysosome
  stored secretory granule
  cytoplasmic vesicle
  glycogen granule
  lipid particle
  contractile fiber
  Golgi apparatus
  Golgi-associated vesicle
  Golgi lumen
  Golgi membrane
  endoplasmic reticulum
  endoplasmic reticulum lumen
  endoplasmic reticulum membrane
  smooth endoplasmic reticulum
  rough endoplasmic reticulum
  ribosome
  mitochondrion
  mitochondrial matrix
  mitochondrial membrane
  cell projection
  neuron projection
  dendrite
  axon
         
cell junction
extracellular matrix
  proteinaceous extracellular matrix
  basement membrane
  basal lamina
extracellular space
  fibrinogen complex
  immunoglobulin complex, circulating
  plasma lipoprotein particle
synapse
  neuromuscular junction
  inhibitory synapse
  excitatory synapse
  synapse part

prioritisation settings show hide
Use these fields to fine-tune prioritisation according to your needs.
When a prioritisation approach has been selected, default values will be filled in. You can change the values according to your needs and thus put more or less emphasis on the different parameters. When a weight is set to 0 (zero), the parameter will be ignored.
    Weight given to the...
Mitopred Mitopred score for prediction of a mitochondrial import sequence
Maestro Maestro score for prediction of a mitochondrial import sequence
OMIM title occurence of a search term in an OMIM title
OMIM clinical symptoms occurence of a search term in an OMIM clinical synposis
OMIM text occurence of a search term in an OMIM report
NCBI geneRIFs occurence of a search term in the NCBI GeneRIFs
MGD phenotype existence of one of the selected MGD (Mouse Genome Database) phenotypes
successive MGD phenotype existence of another selected MGD phenotype
HPO terms existence of one of the specified Human Phenotype Ontology terms (or subclasses)
successive HPO terms existence of another specified Human Phenotype Ontology terms (or subclasses)
expression similarity expression similarity between the candidate gene and other gene(s) specified above under Comparison with known genes
tissue-specific expression tissue-specific expression
cellular localisation specified cellular, extracellular, or organellar localisation (or a sub-localisation thereof)
GO terms existence of one of the specified GO (GeneOntology) terms (or subclasses)
successive GO terms existence of another specified GO terms (or subclasses)
interaction interaction with one of the specified partners (or partners selected by their OMIM disease phenotypes)
successive interaction interaction with another of the specified partners
interaction, successive networks interaction confirmed in another interaction network
PFAM existence of a target PFAM domain
PFAM, successive domain existence of another target PFAM domain
InterPro existence of a target InterPro domain
InterPro, successive domain existence of another target InterPro domain
Kegg pathways member of a target pathway
Kegg, successive pathway member of another target pathway
protein paralogs: identity protein paralogs, weight of sequence identity